User

Prescott

From SYSOS

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Dr Thomas P. Prescott

Post-Doctoral Research Assistant SySOS Control Group, Department of Engineering Science University of Oxford

thomas.prescotteng.ox.ac.uk


Background

I am currently a Post-Doctoral Research Assistant in Control Engineering with Professor Antonis Papachristodoulou, in the SySOS group at the Department of Engineering Science in the University of Oxford. As a student of Trinity College, University of Oxford, I received an MMath in Mathematics in 2008, and in 2015 I completed my DPhil in Engineering Science as part of the Life Sciences Interface Doctoral Training Centre, funded by an EPSRC scholarship. Between these two degrees, I spent two years in a major European tour operator as an Operational Research consultant. My thesis, supervised by Antonis Papachristodoulou, focused on decomposition and reduction techniques for large-scale ODE models, with applications to models used in Systems and Synthetic Biology.

Interests

  • Layered architecture of complex systems
  • Mathematical and Systems Biology
  • Synthetic Biology
  • Networked, multi-scale models of dynamical systems
  • Structured model reduction and error propagation

Additionally, past projects have been in:

My work as an OR consultant at Tui centred on:

  • Yield/revenue management (specifically, using price-sensitive optimization)
  • Search algorithms

Publications

Journal Papers

  1. T. P. Prescott & A. Papachristodoulou. Designing conservation relations in layered synthetic biomolecular networks. IEEE Transactions on Biomedical Circuits and Systems (Synthetic Biology Special Edition), 2015 (in press)
  2. T. P. Prescott, M. Lang, & A. Papachristodoulou. Quantification of interactions between dynamic cellular network functionalities by cascaded layering. PLoS Computational Biology, 11(5):e1004235, 2015 DOI
  3. T. P. Prescott & A. Papachristodoulou. Layered decomposition for the model order reduction of timescale separated biochemical reaction networks. Journal of Theoretical Biology, 356:113-122, 2014 DOI PDF
  4. T. P. Prescott & A. Papachristodoulou. Guaranteed error bounds for structured complexity reduction of biochemical networks. Journal of Theoretical Biology, 304:172-182, 2012 DOI PDF

Peer Reviewed Conference Proceedings

  1. T. P. Prescott & A. Gyorgy. Bounding the effect of retroactivity in the presence of parameter uncertainty. Proceedings of the American Control Conference (ACC), Chicago IL, pp.3120-3125, July 2015
  2. T. P. Prescott & A. Papachristodoulou. Structured storage functions for cascaded systems. Proceedings of the IEEE Conference on Decision and Control (CDC), Los Angeles CA, pp.5488-5493, December 2014 IEEExplore PDF
  3. T. P. Prescott & A. Papachristodoulou. Synthetic Biology: A Control Engineering Perspective. Proceedings of the European Control Conference (ECC), Strasbourg, France, pp.1182-1186, June 2014 IEEExplore PDF
  4. T. P. Prescott & A. Papachristodoulou. Signal propagation across layered biochemical networks. Proceedings of the American Control Conference (ACC), Portland OR, pp.3399-3404, June 2014 IEEExplore PDF
  5. T. P. Prescott & A. Papachristodoulou. Layering in networks: The case of biochemical systems. Proceedings of the American Control Conference (ACC), Washington D.C., pp.4544-4549, June 2013 IEEExplore PDF

Code

Any code associated with published research can be found here.

Teaching

Teaching in Michaelmas (MT) and Hilary (HT) terms at University of Oxford.

  • Class tutor, Engineering Science intercollegiate classes
    • C10.3 Biosystem Modelling (HT2015)
  • Demonstrator, Synthetic Biology CDT
    • Synthetic Circuit Design (HT2015)
    • Systems & Control Theory for Synthetic Biology (HT2015)
    • Introduction to Systems and Synthetic Biology (MT2014)
  • Class tutor, Maths Institute intercollegiate classes
    • C6.2b Networks (HT2014)
  • Teaching Assistant, Maths Institute intercollegiate classes
    • B5a Techniques of Applied Mathematics (MT2013)
    • B5b Applied PDEs (HT2013)
    • B8a Mathematical Biology (MT2012)
  • Class tutor, Biochemistry/Biomedical Sciences
    • Mathematics for Biomedical Sciences Prelims (MT2012 - HT2014)